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Lexeo Therapeutics Reports Interim Data from P-I/II Study of LX2006 to Treat Friedreich Ataxia Cardiomyopathy

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LEXEO THERAPEUTICS

Lexeo Therapeutics Reports Interim Data from P-I/II Study of LX2006 to Treat Friedreich Ataxia Cardiomyopathy

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  • The 52wk. P-I/II (SUNRISE-FA) study assesses LX2006 in FA cardiomyopathy patients across 3 dose-ascending cohorts. Trial will proceed to cohort 3 (1.2x10^12 vg/kg); 1 subject has been dosed & at least 3 are expected
  • Study (n=8 & ≥6mos. follow-up) showed >10% LVMI reduction in 50% of overall patients & 75% of those with elevated LVMI at 12mos.; mean LVMI reduction: 11.4% (12mos.) & 18.3% (18mos.) in elevated LVMI group; reduction in LV wall thickness: 13.6% at 12mos.
  • High-sensitivity troponin I reduced by 53.3% avg. in all patients at 12mos.; frataxin protein expression increased in 3/3 (assessed by LCMS) & 2/2 evaluable patients (assessed by IHC). Further details incl. another cardiac biopsy from cohort 2 is anticipated in Sep 2024

Ref: LEXEO Therapeutics | Image: LEXEO Therapeutics

Related News:- LEXEO Therapeutics Reports the Completion of First Cohort and Dosing in Second Cohort in P-I/II Trial (SUNRISE-FA) of LX2006 for Friedreich’s Ataxia Cardiomyopathy

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Disha Nankani

Disha is a content writer at PharmaShots. She is passionate and curious about recent updates and developments in MedTech and Pharma industry. She covers news related to clinical trial results and updates. She can be contacted at connect@pharmashots.com.

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